- Bad Bunny (111,545,816 followers) reggaeton, trap latino, latin, urbano latino
- KAROL G (63,172,333 followers) reggaeton, latin, urbano latino
- Anuel AA (47,301,855 followers) reggaeton, trap latino, urbano latino, latin
- Ozuna (40,245,724 followers) reggaeton, trap latino, latin, urbano latino
- J Balvin (40,205,462 followers) reggaeton, latin
- Maluma (39,956,024 followers) reggaeton, latin, urbano latino
- Daddy Yankee (38,852,092 followers) reggaeton, latin
- Rauw Alejandro (32,977,677 followers) reggaeton, trap latino, urbano latino, latin
- Paulo Londra (27,412,432 followers) argentine trap, trap latino, reggaeton
- Sebastian Yatra (24,654,415 followers) colombian pop, reggaeton
- Myke Towers (23,377,952 followers) reggaeton, trap latino, urbano latino
- Nicky Jam (21,129,678 followers) reggaeton, latin
- Feid (19,795,770 followers) reggaeton, urbano latino
- Arcángel (18,641,023 followers) reggaeton, trap latino, urbano latino
- Don Omar (17,657,033 followers) reggaeton, urbano latino
- Farruko (17,551,832 followers) reggaeton, trap latino
- Becky G (17,103,061 followers) reggaeton, latin
- Manuel Turizo (16,253,803 followers) reggaeton, pop urbano, colombian pop, latin
- Bryant Myers (14,421,702 followers) trap latino, reggaeton, trap, urbano latino
- Sech (12,105,859 followers) reggaeton, urbano latino
- NATTI NATASHA (11,253,279 followers) reggaeton, latin, urbano latino, bachata
- Blessd (10,303,726 followers) reggaeton, urbano latino, trap latino
- Wisin (10,142,206 followers) reggaeton, latin
- Lunay (9,964,468 followers) reggaeton
- JHAYCO (9,906,824 followers) reggaeton, trap latino, urbano latino
- Piso 21 (9,785,442 followers) reggaeton, colombian pop, pop urbano
- Wisin & Yandel (9,564,703 followers) reggaeton, urbano latino
- CNCO (9,384,379 followers) reggaeton, latin
- Noriel (9,270,128 followers) trap latino, dembow, reggaeton, trap
- Yandel (9,202,872 followers) reggaeton, urbano latino
- Mora (8,799,973 followers) trap latino, urbano latino, reggaeton
- Zion & Lennox (8,650,185 followers) reggaeton, latin
- De La Ghetto (8,032,896 followers) reggaeton, trap latino, urbano latino
- Brytiago (7,938,906 followers) reggaeton, trap latino, urbano latino, trap
- Cris MJ (7,779,823 followers) reggaeton chileno, chilean trap, chilean mambo, reggaeton
- Ñengo Flow (7,631,881 followers) reggaeton, trap latino
- Plan B (7,216,624 followers) reggaeton
- Cosculluela (7,107,605 followers) reggaeton, trap latino, latin hip hop
- Mau y Ricky (6,880,699 followers) latin pop, reggaeton, pop urbano
- Danny Ocean (6,842,587 followers) reggaeton
- J Alvarez (5,847,615 followers) reggaeton, urbano latino
- Nio Garcia (5,668,273 followers) reggaeton
- Lary Over (5,653,668 followers) trap latino, trap, dembow, reggaeton
- KEVIN ROLDAN (5,583,798 followers) reggaeton, urbano latino, trap latino
- Nacho (5,575,502 followers) reggaeton, latin
- Alexis y Fido (5,435,643 followers) reggaeton, urbano latino
- Dalex (5,197,092 followers) reggaeton
- Tego Calderón (5,192,317 followers) reggaeton, latin hip hop
- Justin Quiles (5,166,680 followers) reggaeton
- Ryan Castro (5,034,150 followers) reggaeton
- Darell (5,022,715 followers) reggaeton, trap latino, dembow, urbano latino
- Ñejo (5,002,343 followers) reggaeton
- Jay Wheeler (4,910,110 followers) reggaeton
- Zion (4,747,759 followers) reggaeton
- Jowell & Randy (4,547,950 followers) reggaeton, urbano latino
- Alex Rose (4,545,940 followers) trap latino, reggaeton, urbano latino
- Miky Woodz (4,544,298 followers) trap latino, dembow, reggaeton
- Tito "El Bambino" (4,423,073 followers) reggaeton, urbano latino
- Beéle (4,276,272 followers) latin afrobeats, reggaeton
- Tony Dize (4,173,175 followers) reggaeton
- Tainy (3,934,928 followers) reggaeton
- Lenny Tavárez (3,715,443 followers) reggaeton, urbano latino, trap latino, argentine trap
- Jere Klein (3,559,089 followers) reggaeton chileno, chilean mambo, chilean trap, mambo, rkt, reggaeton
- Baby Rasta y Gringo (3,555,430 followers) reggaeton
- Amenazzy (3,344,390 followers) trap latino, reggaeton, urbano latino, dembow
- Chino & Nacho (3,222,083 followers) merengue, reggaeton, latin
- Reykon (3,122,935 followers) reggaeton, trap latino
- Calle 13 (3,086,253 followers) latin hip hop, latin alternative, reggaeton
- Andy Rivera (3,007,459 followers) reggaeton, popular colombian music, trap latino
- Chris Jedi (2,903,727 followers) trap latino, reggaeton, urbano latino
- Casper Magico (2,775,172 followers) trap latino, reggaeton, urbano latino
- Joey Montana (2,721,503 followers) reggaeton
- Chencho Corleone (2,720,395 followers) reggaeton
- Baby Rasta (2,659,686 followers) reggaeton
- Ivy Queen (2,547,481 followers) reggaeton
- DJ Luian (2,439,930 followers) reggaeton, trap latino
- Lyanno (2,199,808 followers) reggaeton, trap latino, urbano latino
- Jory Boy (2,098,645 followers) reggaeton, trap latino
- Ñejo & Dalmata (2,050,428 followers) reggaeton
- Luny Tunes (2,048,654 followers) reggaeton
- Alkilados (2,034,860 followers) colombian pop, reggaeton, reggae en español
- Dalmata (2,021,105 followers) reggaeton
- Jamby El Favo (2,020,115 followers) trap latino, reggaeton
- El Malilla (1,985,608 followers) reggaeton mexa, reggaeton
- Almighty (1,964,002 followers) trap latino, reggaeton, trap
- Dani Flow (1,867,829 followers) reggaeton mexa, electro corridos, dembow belico, reggaeton
- Bellakath (1,829,499 followers) reggaeton mexa, reggaeton
- El Jordan 23 (1,747,548 followers) reggaeton chileno, chilean trap, chilean mambo, reggaeton mexa, mambo, reggaeton
- El Bogueto (1,722,460 followers) reggaeton mexa, reggaeton
- Juan Magán (1,687,992 followers) reggaeton, latin
- Trebol Clan (1,661,828 followers) reggaeton
- Mario Bautista (1,657,692 followers) reggaeton
- Ovy On The Drums (1,646,361 followers) reggaeton
- Pailita (1,605,716 followers) reggaeton chileno, chilean trap, chilean mambo, mambo, urbano latino, reggaeton
- Luigi 21 Plus (1,570,244 followers) reggaeton
- Juhn (1,532,618 followers) trap latino, reggaeton
- Wolfine (1,466,911 followers) reggaeton
- Standly (1,435,557 followers) reggaeton chileno, chilean trap, chilean mambo, mambo, reggaeton
- Darkiel (1,391,848 followers) reggaeton, urbano latino
- Hector & Tito (1,328,348 followers) reggaeton