- Bad Bunny (121,149,771 followers) reggaeton, trap latino, latin, urbano latino
- KAROL G (66,068,490 followers) reggaeton, latin, urbano latino
- Anuel AA (50,058,605 followers) reggaeton, trap latino, urbano latino, latin
- J Balvin (41,722,900 followers) reggaeton, latin
- Ozuna (41,489,604 followers) reggaeton, trap latino, latin, urbano latino
- Maluma (41,356,056 followers) reggaeton, latin, urbano latino
- Daddy Yankee (40,063,138 followers) reggaeton, latin
- Rauw Alejandro (34,617,087 followers) reggaeton, urbano latino, trap latino, latin
- Paulo Londra (28,249,702 followers) argentine trap, trap latino, reggaeton
- Sebastian Yatra (25,079,194 followers) colombian pop, reggaeton
- Myke Towers (24,806,032 followers) reggaeton, trap latino, urbano latino
- Nicky Jam (21,788,409 followers) reggaeton, latin
- Feid (20,554,591 followers) reggaeton, urbano latino
- Arcángel (19,403,089 followers) reggaeton, trap latino, urbano latino
- Don Omar (19,333,474 followers) reggaeton, urbano latino
- Farruko (18,202,847 followers) reggaeton, trap latino
- Becky G (17,707,872 followers) reggaeton, latin
- Manuel Turizo (16,869,729 followers) reggaeton, colombian pop, latin, pop urbano
- Bryant Myers (15,217,504 followers) trap latino, reggaeton, urbano latino, trap
- Sech (12,234,500 followers) reggaeton, urbano latino
- Blessd (12,135,655 followers) reggaeton, urbano latino
- NATTI NATASHA (11,533,834 followers) reggaeton, latin, urbano latino, bachata
- Wisin (10,603,753 followers) reggaeton, latin
- JHAYCO (10,446,653 followers) reggaeton, trap latino, urbano latino
- Wisin & Yandel (10,211,379 followers) reggaeton, urbano latino
- Lunay (10,081,742 followers) reggaeton
- Piso 21 (9,982,957 followers) reggaeton, colombian pop, pop urbano
- Noriel (9,690,540 followers) trap latino, dembow, reggaeton, trap
- Yandel (9,655,970 followers) reggaeton, urbano latino
- CNCO (9,457,015 followers) reggaeton, latin
- Mora (9,353,726 followers) urbano latino, trap latino, reggaeton
- Zion & Lennox (9,039,491 followers) reggaeton, latin
- Cris MJ (8,440,703 followers) reggaeton chileno, chilean trap, chilean mambo, reggaeton
- De La Ghetto (8,333,860 followers) reggaeton, trap latino, urbano latino
- Brytiago (8,166,153 followers) trap latino, reggaeton, urbano latino, trap
- Ñengo Flow (8,104,066 followers) reggaeton, trap latino
- Plan B (7,922,509 followers) reggaeton
- Cosculluela (7,331,629 followers) reggaeton, trap latino, latin hip hop
- Danny Ocean (7,227,678 followers) reggaeton
- Mau y Ricky (6,990,550 followers) latin pop, reggaeton, pop urbano
- J Alvarez (5,965,683 followers) reggaeton, urbano latino
- Nio Garcia (5,794,338 followers) reggaeton
- Lary Over (5,752,466 followers) trap latino, trap, reggaeton, dembow
- Ryan Castro (5,661,617 followers) reggaeton
- Nacho (5,646,526 followers) reggaeton, latin
- KEVIN ROLDAN (5,614,888 followers) reggaeton, trap latino, urbano latino
- Alexis y Fido (5,556,649 followers) reggaeton, urbano latino
- Tego Calderón (5,488,529 followers) reggaeton, latin hip hop
- Jay Wheeler (5,343,547 followers) reggaeton
- Justin Quiles (5,334,736 followers) reggaeton
- Dalex (5,302,232 followers) reggaeton
- Ñejo (5,190,252 followers) reggaeton
- Darell (5,153,768 followers) reggaeton, trap latino, urbano latino, dembow
- Beéle (5,038,557 followers) latin afrobeats, reggaeton
- Zion (4,951,565 followers) reggaeton
- Alex Rose (4,678,891 followers) trap latino, reggaeton, urbano latino
- Jowell & Randy (4,675,913 followers) reggaeton, urbano latino
- Miky Woodz (4,608,433 followers) trap latino, dembow, reggaeton
- Tito "El Bambino" (4,589,643 followers) reggaeton, urbano latino
- Tainy (4,516,195 followers) reggaeton
- Tony Dize (4,326,078 followers) reggaeton
- Lenny Tavárez (3,899,454 followers) reggaeton, urbano latino, trap latino, argentine trap
- Jere Klein (3,881,671 followers) reggaeton chileno, chilean mambo, chilean trap, mambo, rkt, reggaeton
- Baby Rasta y Gringo (3,649,304 followers) reggaeton
- Amenazzy (3,386,695 followers) trap latino, urbano latino, reggaeton, dembow
- Chino & Nacho (3,323,868 followers) merengue, reggaeton, latin
- Chencho Corleone (3,279,292 followers) reggaeton
- Calle 13 (3,162,497 followers) latin hip hop, latin alternative, reggaeton
- Reykon (3,141,606 followers) reggaeton, trap latino
- Andy Rivera (3,022,129 followers) reggaeton, popular colombian music, trap latino
- Chris Jedi (2,991,495 followers) trap latino, reggaeton, urbano latino
- Casper Magico (2,891,896 followers) trap latino, reggaeton, urbano latino
- Baby Rasta (2,867,408 followers) reggaeton
- Joey Montana (2,749,450 followers) reggaeton
- Ivy Queen (2,584,306 followers) reggaeton
- DJ Luian (2,531,776 followers) reggaeton, trap latino
- Lyanno (2,387,374 followers) reggaeton, trap latino, urbano latino
- Almighty (2,182,200 followers) trap latino, reggaeton, trap
- Jory Boy (2,177,775 followers) reggaeton, trap latino
- Luny Tunes (2,174,887 followers) reggaeton
- El Bogueto (2,142,601 followers) reggaeton mexa, reggaeton
- El Malilla (2,110,661 followers) reggaeton mexa, reggaeton
- Ñejo & Dalmata (2,094,039 followers) reggaeton
- Dalmata (2,079,008 followers) reggaeton
- Alkilados (2,046,397 followers) colombian pop, reggaeton, reggae en español
- Dani Flow (1,927,197 followers) reggaeton mexa, electro corridos, dembow belico, reggaeton
- Bellakath (1,876,318 followers) reggaeton mexa, reggaeton
- El Jordan 23 (1,809,058 followers) reggaeton chileno, chilean trap, chilean mambo, reggaeton mexa, mambo, reggaeton
- Ovy On The Drums (1,802,160 followers) reggaeton
- Juan Magán (1,724,611 followers) reggaeton, latin
- Trebol Clan (1,684,826 followers) reggaeton
- Mario Bautista (1,662,886 followers) reggaeton
- Pailita (1,625,642 followers) reggaeton chileno, chilean trap, chilean mambo, mambo, urbano latino, reggaeton
- Luigi 21 Plus (1,624,549 followers) reggaeton
- Juhn (1,591,028 followers) trap latino, reggaeton
- Héctor "El Father" (1,542,052 followers) reggaeton
- Standly (1,523,255 followers) reggaeton chileno, chilean trap, chilean mambo, mambo, reggaeton
- Wolfine (1,486,958 followers) reggaeton
- Darkiel (1,415,936 followers) reggaeton, urbano latino
- Hector & Tito (1,394,096 followers) reggaeton