- Mon Laferte (11,534,701 followers) latin alternative
- Soda Stereo (10,357,889 followers) rock en español, latin rock, argentine rock, latin alternative
- Zoé (8,176,963 followers) rock en español, mexican rock, mexican indie, latin alternative, latin indie, latin rock
- Gustavo Cerati (5,773,534 followers) argentine rock, latin rock, rock en español, latin alternative
- Natalia Lafourcade (5,576,077 followers) latin folk, bolero, latin indie, latin alternative, latin folklore
- Los Enanitos Verdes (5,519,249 followers) rock en español, latin rock, argentine rock, mexican rock, latin alternative
- Caifanes (5,338,265 followers) rock en español, mexican rock, latin rock, latin alternative
- Café Tacvba (3,940,060 followers) rock en español, mexican rock, latin rock, latin alternative, ska
- Los Fabulosos Cadillacs (3,436,512 followers) rock en español, latin rock, ska, argentine rock, latin alternative, mexican ska, murga
- Panteon Rococo (3,129,004 followers) ska, mexican ska, rock en español, mexican rock, latin alternative
- Calle 13 (3,086,253 followers) latin hip hop, latin alternative, reggaeton
- León Larregui (3,052,440 followers) rock en español, mexican indie, latin indie, latin alternative
- Heroes Del Silencio (3,044,277 followers) rock en español, latin rock, mexican rock, latin alternative
- No Te Va Gustar (2,727,819 followers) argentine rock, murga, latin rock, rock en español, latin alternative
- Molotov (2,555,803 followers) rock en español, mexican rock, latin rock, ska, latin alternative, mexican hip hop, latin hip hop
- Los Auténticos Decadentes (2,542,621 followers) argentine rock, latin rock, ska, rock en español, murga, latin alternative
- Manu Chao (2,049,129 followers) latin alternative
- Jarabe De Palo (1,901,489 followers) rock en español, latin rock, latin alternative
- Cultura Profética (1,882,023 followers) reggae en español, reggae, roots reggae, latin alternative
- Babasonicos (1,843,565 followers) argentine rock, rock en español, latin rock, latin alternative
- Los Bunkers (1,734,734 followers) latin rock, rock en español, latin alternative
- Siddhartha (1,716,934 followers) mexican indie, latin indie, latin alternative, rock en español
- Ximena Sariñana (1,699,009 followers) latin indie, mexican indie, latin alternative
- La Ley (1,689,777 followers) rock en español, latin rock, latin alternative
- Jaguares (1,685,421 followers) rock en español, mexican rock, latin rock, latin alternative
- Control Machete (1,490,286 followers) mexican hip hop, latin hip hop, rock en español, mexican rock, latin alternative
- Los Pericos (1,454,818 followers) reggae en español, reggae, argentine rock, latin rock, rock en español, ska, latin alternative
- El Gran Silencio (1,273,414 followers) rock en español, ska, mexican rock, mexican ska, latin alternative, latin rock
- Bomba Estéreo (1,188,086 followers) latin alternative, electrocumbia
- Mœnia (1,027,849 followers) rock en español, latin pop, latin alternative
- Bersuit Vergarabat (1,021,145 followers) argentine rock, latin rock, rock en español, latin alternative, murga
- Caloncho (930,478 followers) latin indie, mexican indie, latin alternative
- Aterciopelados (909,990 followers) rock en español, latin rock, latin alternative
- La Gusana Ciega (903,451 followers) rock en español, mexican rock, latin alternative, mexican indie, latin rock
- Plastilina Mosh (775,850 followers) rock en español, mexican rock, latin alternative, mexican indie, latin rock
- Camilo Séptimo (715,545 followers) mexican indie, latin indie, latin alternative, rock en español
- ChocQuibTown (685,258 followers) salsa choke, colombian pop, latin alternative
- Monsieur Periné (665,628 followers) colombian pop, latin alternative, latin indie
- Los Tres (642,865 followers) latin rock, rock en español, latin alternative
- Esteman (602,887 followers) latin indie, latin alternative, mexican indie
- Kinky (562,691 followers) rock en español, mexican rock, latin alternative, mexican indie
- Orishas (540,379 followers) latin hip hop, latin alternative, son cubano, latin
- Little Jesus (519,169 followers) mexican indie, latin indie, latin alternative
- Salon Victoria (500,108 followers) ska, mexican ska, rock en español, mexican rock, latin alternative
- Los Amigos Invisibles (493,422 followers) rock en español, latin alternative, latin rock
- La Lupita (478,887 followers) rock en español, mexican rock, ska, mexican ska, latin alternative, latin rock
- Lila Downs (471,292 followers) trova, latin folklore, latin folk, latin alternative, mariachi, son jarocho
- Bandalos Chinos (470,473 followers) latin indie, mexican indie, latin alternative
- Porter (450,338 followers) mexican indie, latin indie, mexican rock, latin alternative, rock en español, latin rock
- Ely Guerra (428,444 followers) mexican rock, rock en español, latin alternative, mexican indie
- Macaco (413,734 followers) reggae en español, latin alternative
- Quantic (398,815 followers) nu jazz, trip hop, downtempo, electrocumbia, acid jazz, latin alternative
- Los Amantes De Lola (396,042 followers) rock en español, mexican rock, latin rock, latin alternative
- Kevin Johansen (395,063 followers) latin folk, trova, latin alternative
- Hello Seahorse! (376,224 followers) mexican indie, latin indie, mexican rock, latin alternative, rock en español
- Gepe (368,165 followers) latin indie, latin alternative, latin folk
- Odisseo (348,891 followers) mexican indie, latin indie, latin alternative, latin rock, mexican rock, rock en español
- Chetes (344,985 followers) mexican indie, rock en español, mexican rock, latin alternative, latin indie
- Elsa y Elmar (340,740 followers) latin indie, mexican indie, latin alternative
- Joe Vasconcellos (335,340 followers) latin rock, latin alternative
- Reyno (330,565 followers) mexican indie, latin indie, latin alternative, latin rock, mexican rock
- Tijuana No! (329,992 followers) ska, mexican ska, rock en español, mexican rock, latin alternative, latin rock
- Chico Trujillo (324,037 followers) cumbia, chicha, latin alternative
- Volován (321,923 followers) rock en español, mexican rock, mexican indie, latin alternative
- Jumbo (321,605 followers) rock en español, mexican rock, latin alternative, mexican indie, latin rock
- Illya Kuryaki & The Valderramas (320,040 followers) rock en español, argentine rock, latin rock, latin alternative
- Mano Negra (316,884 followers) latin alternative, rock en español, latin rock
- Natalia y La Forquetina (304,364 followers) latin alternative
- Comisario Pantera (290,691 followers) mexican indie, latin indie, latin alternative, mexican rock, rock en español
- Technicolor Fabrics (273,567 followers) mexican indie, latin indie, latin alternative
- Los Mesoneros (263,828 followers) latin indie, latin alternative, mexican indie
- maye (263,633 followers) latin indie, latin alternative
- La Santa Cecilia (252,569 followers) bolero, latin alternative, latin folk, latin indie
- Chicano Batman (250,164 followers) latin indie, latin alternative
- Daniela Spalla (249,909 followers) latin indie, mexican indie, latin alternative
- Los De Abajo (227,727 followers) ska, mexican ska, mexican rock, latin alternative, rock en español
- Onda Vaga (212,469 followers) latin folk, latin alternative
- Todos Tus Muertos (196,940 followers) ska, argentine rock, reggae en español, rock en español, latin alternative, mexican ska, latin rock, ska punk
- Javiera Mena (196,303 followers) latin indie, latin alternative, electropop
- Nortec Collective (185,333 followers) latin alternative, electrocumbia, mexican rock
- Los Espiritus (178,996 followers) latin indie, argentine rock, latin rock, latin alternative, neo-psychedelic
- Girl Ultra (176,383 followers) latin indie, latin r&b, mexican indie, latin alternative
- Mexican Institute Of Sound (174,170 followers) electrocumbia, latin alternative, mexican indie
- Systema Solar (173,275 followers) electrocumbia, champeta, latin alternative
- Sussie 4 (170,239 followers) mexican indie, latin alternative
- CLUBZ (164,210 followers) latin indie, mexican indie, latin alternative
- Los Concorde (157,627 followers) rock en español, mexican rock, mexican indie, latin alternative
- Desorden Público (157,422 followers) ska, latin alternative, latin rock, rock en español, mexican ska
- Draco Rosa (156,820 followers) rock en español, latin pop, latin rock, latin alternative
- Juan Son (155,831 followers) mexican indie, latin indie, latin alternative, mexican rock
- Helado Negro (155,405 followers) latin alternative, latin indie
- La Garfield (150,854 followers) latin indie, reggae en español, mexican indie, latin alternative
- Doctor Krápula (150,854 followers) rock en español, colombian pop, ska, latin alternative
- Bengala (148,639 followers) mexican indie, mexican rock, rock en español, latin indie, latin alternative
- Los Romanticos de Zacatecas (146,259 followers) mexican indie, latin indie, mexican rock, latin alternative, rock en español
- Camila Moreno (145,221 followers) latin folk, trova, latin indie, latin alternative
- iLe (144,847 followers) latin indie, latin alternative, latin folk
- Juan Pablo Vega (143,644 followers) reggae en español, latin indie, latin alternative
- Alex Anwandter (141,784 followers) latin indie, latin alternative, electropop
- Surfistas Del Sistema (140,173 followers) latin indie, mexican indie, latin alternative