- Dr. John (272,486 followers) cajun, zydeco
- Tony Joe White (171,168 followers) blues rock, blues, country blues, cajun
- Tab Benoit (108,721 followers) cajun, modern blues, zydeco, blues rock, blues, country blues
- Allen Toussaint (108,429 followers) cajun
- Preservation Hall Jazz Band (91,825 followers) brass band, swing music, ragtime, cajun, jazz
- The Neville Brothers (87,057 followers) cajun, zydeco
- Clarence "Gatemouth" Brown (79,463 followers) classic blues, blues, modern blues, zydeco, blues rock, cajun, boogie-woogie
- Rebirth Brass Band (68,541 followers) brass band, zydeco, cajun, new orleans bounce
- Sonny Landreth (62,578 followers) blues rock, modern blues, blues, cajun, zydeco
- Texas Tornados (61,610 followers) tejano, latin country, cajun
- Professor Longhair (59,657 followers) cajun, zydeco, classic blues, boogie-woogie, brass band
- The Dirty Dozen Brass Band (51,161 followers) brass band, jam band, cajun, zydeco
- Salebarbes (42,687 followers) chanson québécoise, cajun, rock québécois, folk québécois, chanson
- The Soul Rebels (40,551 followers) brass band, new orleans bounce, cajun
- Cayouche (28,713 followers) chanson québécoise, rock québécois, folk québécois, cajun
- Snooks Eaglin (28,182 followers) classic blues, country blues, blues, cajun
- James Booker (27,198 followers) boogie-woogie, cajun, ragtime, zydeco
- Lazy Lester (26,911 followers) classic blues, blues, blues rock, modern blues, cajun
- Kermit Ruffins (26,521 followers) brass band, cajun
- Jon Cleary (26,099 followers) cajun, jazz funk
- Flaco Jimenez (25,399 followers) tejano, polka, latin country, cajun
- Marcia Ball (24,366 followers) zydeco, blues, cajun, boogie-woogie, modern blues
- Keith Frank (23,997 followers) zydeco, cajun
- Buckwheat Zydeco (22,797 followers) zydeco, cajun
- Bobby Charles (22,474 followers) cajun, zydeco
- Chris Ardoin (21,659 followers) zydeco, cajun
- Wayne Toups (21,191 followers) cajun, zydeco
- Féloche (20,441 followers) cajun
- The Subdudes (20,400 followers) cajun, zydeco, roots rock, americana
- Guitar Slim (19,537 followers) classic blues, country blues, blues, cajun
- Le Vent du Nord (18,658 followers) folk québécois, traditional music, celtic, chanson québécoise, cajun, folk
- Dale Hawkins (18,211 followers) rockabilly, psychobilly, rock and roll, cajun
- Clifton Chenier (17,966 followers) zydeco, cajun
- Bonerama (17,816 followers) brass band, cajun
- Cajun Dance Party (17,034 followers) cajun
- Earl King (15,838 followers) classic blues, new orleans bounce, cajun, zydeco
- Arbo (14,589 followers) cajun
- Lil' Nathan & The Zydeco Big Timers (14,351 followers) zydeco, cajun
- Big Sam's Funky Nation (13,917 followers) brass band, jazz funk, funk, cajun
- The Radiators (13,794 followers) jam band, cajun, zydeco, roots rock, italo disco, southern rock
- J. Paul Jr And The Zydeco Nubreeds (13,771 followers) zydeco, cajun, new orleans bounce
- The Wild Tchoupitoulas (13,497 followers) cajun, zydeco, brass band, native american music
- Zachary Richard (13,286 followers) cajun, zydeco, chanson québécoise, rock québécois, folk québécois, pop québécoise
- Sweet Crude (12,396 followers) cajun
- John Boutté (11,845 followers) brass band, cajun, zydeco
- Treme Brass Band (11,604 followers) brass band, cajun, zydeco
- The New Lost City Ramblers (11,147 followers) bluegrass, traditional folk, folk, cajun
- Keith Frank & The Soileau Zydeco Band (10,979 followers) zydeco, cajun
- BeauSoleil (10,254 followers) cajun, zydeco
- Foghorn Stringband (9,842 followers) bluegrass, cajun, newgrass, traditional folk
- Lost Bayou Ramblers (9,422 followers) cajun, zydeco
- The Wild Magnolias (9,331 followers) cajun, zydeco, brass band
- New Birth Brass Band (9,239 followers) brass band, cajun, zydeco
- Cha Wa (8,580 followers) brass band, cajun
- Art Neville (8,294 followers) cajun, zydeco, classic blues, blues
- Les Gars Du Nord (8,290 followers) chanson québécoise, folk québécois, cajun
- Bruce Molsky (8,118 followers) bluegrass, traditional folk, cajun
- Donald Harrison (7,777 followers) brass band, cajun, jazz, jazz ballads
- Hert Leblanc (7,742 followers) cajun
- The Balfa Brothers (7,741 followers) cajun, zydeco, folk québécois
- Canailles (7,627 followers) folk québécois, cajun, chanson québécoise
- New Orleans Nightcrawlers (7,430 followers) brass band, cajun, zydeco
- Ryan Foret And Foret Tradition (7,426 followers) cajun, zydeco
- Honey Island Swamp Band (7,378 followers) cajun
- Dirk Powell (7,371 followers) bluegrass, cajun, newgrass, traditional folk, americana
- Doug Kershaw (7,355 followers) cajun, zydeco
- Glen David Andrews (7,212 followers) brass band, cajun, zydeco
- The Iguanas (7,080 followers) proto-punk, garage rock, cajun, zydeco
- Beau Jocque and the Zydeco Hi-Rollers (7,071 followers) zydeco, cajun
- Mojo Blues Band (7,050 followers) boogie-woogie, boogie, blues rock, blues, cajun, rockabilly, swing music
- Dustin Sonnier (7,030 followers) texas country, cajun, red dirt, zydeco, traditional country
- 1755 (6,937 followers) rock québécois, cajun, folk québécois, chanson québécoise
- Benjy Davis Project (6,858 followers) cajun
- Dave Bartholomew (6,563 followers) cajun
- Horace Trahan (6,285 followers) zydeco, cajun
- Lil Nathan (6,088 followers) zydeco, cajun
- Chris Ardoin & Double Clutchin' (6,062 followers) zydeco, cajun
- Laurie LeBlanc (6,050 followers) cajun
- Geno Delafose (6,030 followers) zydeco, cajun
- Jourdan Thibodeaux et les Rôdailleurs (5,894 followers) cajun, zydeco, folk québécois
- Charlo (5,785 followers) tango, cajun, zydeco, candombe
- Moon Mullican (5,782 followers) rockabilly, cajun, honky tonk, traditional country, boogie-woogie
- Nump (5,662 followers) hyphy, west coast hip hop, zydeco, cajun
- Aly Bain (5,599 followers) celtic, cajun, folk, zydeco
- J. Paul Jr. (5,542 followers) zydeco, cajun
- Brian Jack and the Zydeco Gamblers (5,522 followers) zydeco, cajun
- Steve Riley & The Mamou Playboys (5,489 followers) cajun, zydeco
- Jamie Bergeron & The Kickin' Cajuns (5,264 followers) cajun, zydeco
- Boozoo Chavis (5,233 followers) zydeco, cajun
- La Famille LeBlanc (5,205 followers) cajun, celtic rock, celtic, traditional music, zydeco
- Flow Tribe (5,158 followers) funk rock, cajun
- Nathan & the Zydeco Cha Chas (5,064 followers) zydeco, cajun
- Rheal LeBlanc (5,010 followers) cajun
- Pine Leaf Boys (4,943 followers) cajun, zydeco
- Cedric Watson (4,889 followers) cajun, zydeco
- Jo-El Sonnier (4,875 followers) cajun, zydeco
- Travis Matte And The Zydeco Kingpins (4,834 followers) zydeco, cajun
- Quimorucru (4,773 followers) folk québécois, cajun, chanson québécoise
- Rayna Gellert (4,754 followers) bluegrass, cajun, americana
- Tommy McLain (4,713 followers) cajun, zydeco