- Dr. John (265,174 followers) cajun, zydeco
- Allen Toussaint (104,431 followers) cajun
- Tab Benoit (104,121 followers) blues, cajun, modern blues, zydeco, blues rock, country blues
- Preservation Hall Jazz Band (88,390 followers) brass band, swing music, ragtime, cajun, jazz
- The Neville Brothers (83,618 followers) cajun, zydeco
- Rebirth Brass Band (66,661 followers) brass band, zydeco, cajun, new orleans bounce
- Sonny Landreth (61,199 followers) blues, blues rock, modern blues, cajun, zydeco
- Texas Tornados (58,298 followers) tejano, latin country, cajun
- Professor Longhair (57,842 followers) cajun, zydeco, classic blues, boogie-woogie, blues, brass band
- The Dirty Dozen Brass Band (50,049 followers) brass band, jam band, cajun, zydeco
- Choppa (44,653 followers) new orleans bounce, bounce, zydeco, cajun
- Salebarbes (40,071 followers) chanson québécoise, cajun, rock quebecois, folk québécois, chanson
- The Soul Rebels (39,443 followers) brass band, new orleans bounce, cajun
- Cayouche (27,404 followers) chanson québécoise, rock quebecois, folk québécois, cajun, chanson
- Kermit Ruffins (25,817 followers) brass band, cajun
- James Booker (25,449 followers) boogie-woogie, cajun, ragtime, blues
- Jon Cleary (25,161 followers) cajun, jazz funk
- Flaco Jimenez (24,209 followers) tejano, polka, latin country, cajun
- Marcia Ball (23,622 followers) zydeco, cajun, blues, boogie-woogie, modern blues
- Keith Frank (22,318 followers) zydeco, cajun
- Buckwheat Zydeco (21,855 followers) zydeco, cajun
- Bobby Charles (20,302 followers) cajun, zydeco
- Chris Ardoin (20,122 followers) zydeco, cajun
- Wayne Toups (19,841 followers) cajun, zydeco
- Féloche (19,470 followers) cajun
- The Subdudes (19,439 followers) cajun, zydeco, roots rock, americana
- Le Vent du Nord (17,931 followers) folk québécois, traditional music, celtic, chanson québécoise, cajun, folk
- Bonerama (17,380 followers) brass band, cajun
- Clifton Chenier (17,019 followers) zydeco, cajun
- Cajun Dance Party (16,717 followers) cajun
- Earl King (15,201 followers) new orleans bounce, classic blues, cajun, blues, zydeco
- Arbo (14,318 followers) cajun
- Big Sam's Funky Nation (13,693 followers) brass band, jazz funk, funk, cajun
- The Radiators (13,366 followers) jam band, cajun, zydeco, roots rock, italo disco
- Lil' Nathan & The Zydeco Big Timers (13,118 followers) zydeco, cajun
- The Wild Tchoupitoulas (12,868 followers) cajun, zydeco, brass band, native american music
- J. Paul Jr And The Zydeco Nubreeds (12,795 followers) zydeco, cajun
- Zachary Richard (12,528 followers) cajun, zydeco, chanson québécoise, rock quebecois, folk québécois, pop québécoise
- Sweet Crude (12,256 followers) cajun
- John Boutté (11,576 followers) brass band, cajun, zydeco
- Treme Brass Band (11,389 followers) brass band, cajun, zydeco
- The New Lost City Ramblers (10,891 followers) bluegrass, traditional folk, folk, cajun
- Keith Frank & The Soileau Zydeco Band (10,139 followers) zydeco, cajun
- BeauSoleil (9,809 followers) cajun, zydeco
- Foghorn Stringband (9,465 followers) bluegrass, cajun, newgrass, traditional folk
- New Birth Brass Band (9,094 followers) brass band, cajun, zydeco
- Lost Bayou Ramblers (9,058 followers) cajun, zydeco
- The Wild Magnolias (9,007 followers) cajun, zydeco, brass band
- Cha Wa (8,367 followers) brass band, cajun
- Bruce Molsky (7,849 followers) bluegrass, traditional folk, cajun
- Canailles (7,474 followers) folk québécois, cajun, chanson québécoise, rock quebecois
- Donald Harrison (7,426 followers) brass band, cajun, jazz, jazz ballads
- The Balfa Brothers (7,317 followers) cajun, zydeco, folk québécois
- New Orleans Nightcrawlers (7,292 followers) brass band, cajun, zydeco
- Hert Leblanc (7,256 followers) cajun
- Dirk Powell (6,952 followers) bluegrass, cajun, newgrass, traditional folk, americana
- Doug Kershaw (6,939 followers) cajun, zydeco
- Ryan Foret And Foret Tradition (6,890 followers) cajun, zydeco
- Honey Island Swamp Band (6,853 followers) cajun
- The Iguanas (6,767 followers) garage rock, cajun, proto-punk, zydeco
- Dustin Sonnier (6,763 followers) texas country, cajun, red dirt, zydeco, traditional country
- Beau Jocque and the Zydeco Hi-Rollers (6,741 followers) zydeco, cajun
- Benjy Davis Project (6,647 followers) cajun
- 1755 (6,571 followers) rock quebecois, cajun, folk québécois, chanson québécoise
- Glen David Andrews (6,471 followers) brass band, cajun, zydeco
- Dave Bartholomew (6,326 followers) cajun
- Lil Nathan (6,088 followers) zydeco, cajun
- Chris Ardoin & Double Clutchin' (5,857 followers) zydeco, cajun
- Moon Mullican (5,782 followers) rockabilly, cajun, honky tonk, traditional country, boogie-woogie
- Geno Delafose (5,727 followers) zydeco, cajun
- Laurie LeBlanc (5,705 followers) cajun
- Horace Trahan (5,680 followers) zydeco, cajun
- Charlo (5,620 followers) tango, cajun, zydeco, candombe
- Nump (5,460 followers) hyphy, west coast hip hop, cajun, zydeco
- Aly Bain (5,396 followers) celtic, cajun, folk, zydeco
- J. Paul Jr. (5,364 followers) zydeco, cajun
- Jourdan Thibodeaux et les Rôdailleurs (5,344 followers) cajun, zydeco, folk québécois
- Steve Riley & The Mamou Playboys (5,164 followers) cajun, zydeco
- Lennie Gallant (5,037 followers) cajun
- Brian Jack and the Zydeco Gamblers (5,034 followers) zydeco, cajun
- Boozoo Chavis (4,973 followers) zydeco, cajun
- Jamie Bergeron & The Kickin' Cajuns (4,888 followers) cajun, zydeco
- Nathan & the Zydeco Cha Chas (4,854 followers) zydeco, cajun
- Rheal LeBlanc (4,768 followers) cajun
- Pine Leaf Boys (4,736 followers) cajun, zydeco
- Tommy McLain (4,713 followers) cajun, zydeco
- Cedric Watson (4,663 followers) cajun, zydeco
- Jo-El Sonnier (4,649 followers) cajun, zydeco
- Rayna Gellert (4,645 followers) bluegrass, cajun, americana
- De Temps Antan (4,562 followers) folk québécois, traditional music, chanson québécoise, cajun
- Travis Matte And The Zydeco Kingpins (4,516 followers) zydeco, cajun
- LSU Tiger Marching Band (4,505 followers) cajun
- Quimorucru (4,426 followers) folk québécois, cajun, chanson québécoise
- Les Hôtesses D' Hilaire (4,412 followers) rock québécois, cajun, pop québécoise
- C.J. Chenier (4,312 followers) zydeco, cajun
- Dr. Michael White (4,267 followers) ragtime, brass band, cajun, zydeco
- LeRoux (4,238 followers) aor, cajun, arena rock, zydeco, southern rock
- Red Stick Ramblers (4,163 followers) cajun, zydeco, bluegrass
- Tatiana Hargreaves (4,152 followers) bluegrass, cajun, newgrass, traditional folk
- Suroît (4,143 followers) folk québécois, cajun