- B.B. King (2,938,203 followers) classic blues, blues, blues rock, soul blues
- Stevie Ray Vaughan (2,708,021 followers) blues rock, classic blues, blues, southern rock, modern blues, classic rock
- Muddy Waters (1,392,428 followers) classic blues, blues, blues rock, soul blues, country blues
- Joe Bonamassa (1,040,508 followers) blues rock, modern blues, blues, classic blues
- John Lee Hooker (952,839 followers) classic blues, blues, blues rock, country blues, soul blues
- Buddy Guy (913,623 followers) classic blues, blues, blues rock, modern blues, soul blues, country blues
- Gary Moore (908,372 followers) blues rock, blues, modern blues
- Bonnie Raitt (851,327 followers) blues
- Robert Johnson (651,433 followers) classic blues, country blues, blues, blues rock
- Howlin' Wolf (582,228 followers) classic blues, blues, blues rock, country blues, soul blues
- Johnny Winter (529,443 followers) blues rock, classic blues, blues, modern blues, southern rock
- Tedeschi Trucks Band (529,383 followers) jam band, modern blues, blues rock, southern rock, blues
- Rory Gallagher (524,272 followers) blues rock, modern blues, classic blues, blues
- Beth Hart (506,918 followers) blues, blues rock, modern blues
- Albert King (506,480 followers) classic blues, blues, blues rock, soul blues, modern blues
- The Blues Brothers (470,265 followers) blues, blues rock
- John Mayall & The Bluesbreakers (446,968 followers) blues rock, classic blues, blues, modern blues
- Freddie King (435,000 followers) classic blues, blues, blues rock, soul blues, modern blues
- Keb' Mo' (385,374 followers) modern blues, blues, country blues, blues rock, classic blues, soul blues
- Kenny Wayne Shepherd (384,768 followers) blues rock, modern blues, blues, southern rock
- Bo Diddley (344,262 followers) classic blues, rock and roll, rockabilly, blues, roots rock
- Gov't Mule (318,620 followers) jam band, southern rock, blues rock, modern blues, blues
- Lightnin' Hopkins (296,433 followers) classic blues, country blues, blues, blues rock, soul blues
- Larkin Poe (295,960 followers) blues rock, modern blues, blues, roots rock
- Robert Cray (278,613 followers) modern blues, blues rock, blues, soul blues, classic blues
- John Mayall (275,508 followers) blues rock, blues, modern blues, classic blues, soul blues
- Jonny Lang (273,462 followers) blues rock, modern blues, blues, classic blues
- Johnnie Taylor (266,653 followers) blues, soul blues, zydeco, footwork, classic soul, soul
- Peter Green (265,291 followers) blues rock, blues, classic blues
- Taj Mahal (257,822 followers) classic blues, blues, country blues, blues rock, modern blues
- Christone "Kingfish" Ingram (253,262 followers) modern blues, blues rock, blues, classic blues, soul blues
- King George (253,262 followers) zydeco, footwork, blues
- The Jeff Healey Band (243,186 followers) blues rock, blues, modern blues
- The Derek Trucks Band (241,976 followers) jam band, modern blues, blues rock, southern rock, blues
- Susan Tedeschi (241,627 followers) blues, modern blues, blues rock
- Little Walter (235,455 followers) classic blues, blues, soul blues, blues rock
- T-Bone Walker (229,472 followers) classic blues, blues, blues rock, soul blues
- Albert Collins (225,468 followers) classic blues, blues, blues rock, modern blues, soul blues
- Lead Belly (225,206 followers) classic blues, country blues, blues, folk, traditional folk, ragtime
- Big Mama Thornton (219,386 followers) classic blues, blues, soul blues
- Elmore James (213,436 followers) classic blues, blues, blues rock, soul blues
- Sister Rosetta Tharpe (209,986 followers) traditional gospel, blues, classic blues, swing music, roots rock
- Sonny Boy Williamson II (208,414 followers) classic blues, blues, country blues, blues rock, soul blues
- Tyrone Davis (206,944 followers) blues, zydeco, classic soul, footwork, northern soul, soul, soul blues
- Ehud Banai (202,734 followers) blues, mizrahi
- Bobby "Blue" Bland (198,784 followers) classic blues, soul blues, blues, soul, classic soul
- The Vaughan Brothers (198,329 followers) blues rock, blues, modern blues, southern rock, classic blues
- The Fabulous Thunderbirds (196,662 followers) classic blues, blues rock, southern rock, blues, modern blues
- Roy Buchanan (194,083 followers) blues, blues rock, classic blues, modern blues
- Otis Rush (190,554 followers) classic blues, blues, blues rock, soul blues, modern blues
- R.L. Burnside (190,505 followers) country blues, modern blues, blues rock, classic blues, blues
- Shalom Hanoch (175,940 followers) mizrahi, blues
- Tony Joe White (171,168 followers) blues rock, blues, country blues, cajun
- Son House (170,545 followers) classic blues, country blues, blues, blues rock
- Willie Dixon (169,440 followers) classic blues, blues, blues rock, soul blues
- Meir Ariel (165,348 followers) blues
- Bessie Smith (165,198 followers) classic blues, blues, ragtime, jazz, vocal jazz
- Samantha Fish (160,426 followers) blues, modern blues, blues rock, country blues
- Jimmie Vaughan (157,665 followers) blues rock, blues, classic blues, modern blues, soul blues
- Jimmy Reed (151,412 followers) classic blues, blues, blues rock, soul blues
- Mississippi John Hurt (149,936 followers) country blues, classic blues, blues, ragtime, traditional folk, folk
- Savoy Brown (148,665 followers) blues rock, modern blues, psychedelic rock, blues
- Snowy White (147,483 followers) blues, blues rock, modern blues
- Alvin Lee (146,368 followers) blues rock, blues, modern blues
- Enlly Blue (142,202 followers) soul blues, blues
- Koko Taylor (141,090 followers) classic blues, blues, soul blues, blues rock, modern blues
- Sir Charles Jones (139,432 followers) zydeco, blues, footwork, soul blues
- Walter Trout (136,575 followers) blues rock, modern blues, blues, classic blues
- Junior Wells (131,102 followers) classic blues, blues, blues rock, modern blues, soul blues
- Justin Johnson (126,974 followers) blues, southern gothic, country blues, blues rock
- Marvin Sease (123,046 followers) blues, zydeco, footwork, soul blues
- Eric Gales (122,935 followers) modern blues, blues rock, blues, classic blues
- Robben Ford (122,110 followers) modern blues, blues rock, blues, jazz fusion, soul blues, classic blues
- Shirley Brown (121,358 followers) classic soul, soul, blues
- Joanne Shaw Taylor (121,356 followers) blues, blues rock, modern blues, classic blues, soul blues
- The Paul Butterfield Blues Band (121,321 followers) blues rock, classic blues, blues, modern blues
- The Robert Cray Band (120,413 followers) modern blues, blues rock, blues, soul blues, classic blues
- Blind Willie Johnson (118,634 followers) classic blues, country blues, blues, southern gothic
- Tab Benoit (108,721 followers) cajun, modern blues, zydeco, blues rock, blues, country blues
- Jackie Venson (104,702 followers) blues, modern blues, blues rock, soul blues
- Jeff Healey (104,352 followers) blues rock, modern blues, blues, classic blues
- Mike Bloomfield (100,886 followers) classic blues, blues, blues rock, modern blues
- Memphis Slim (96,609 followers) classic blues, boogie-woogie, blues, soul blues
- Z.Z. Hill (96,509 followers) soul blues, blues, northern soul, footwork, zydeco, classic blues
- T.K. Soul (92,284 followers) zydeco, blues, footwork, soul blues
- Delbert McClinton (91,490 followers) blues rock, blues, country blues
- Luther Allison (90,749 followers) classic blues, blues, blues rock, modern blues, soul blues
- Philip Sayce (89,372 followers) blues rock, modern blues, blues
- Mel Waiters (88,855 followers) zydeco, blues, footwork, soul blues
- Ana Popovic (86,401 followers) blues, modern blues, blues rock, soul blues, funk rock
- Junior Kimbrough (85,846 followers) country blues, classic blues, blues, modern blues, blues rock
- Denise LaSalle (85,715 followers) soul blues, blues, northern soul, footwork, zydeco
- Popa Chubby (85,342 followers) blues rock, modern blues, blues
- Skip James (82,838 followers) country blues, classic blues, blues, ragtime
- Tucka (80,242 followers) zydeco, blues, footwork, soul blues, swing music, new orleans bounce
- Charley Patton (79,593 followers) country blues, classic blues, blues, ragtime, experimental jazz
- Clarence "Gatemouth" Brown (79,463 followers) classic blues, blues, modern blues, zydeco, blues rock, cajun, boogie-woogie
- Eilen Jewell (79,245 followers) americana, alt country, blues
- Magic Sam (78,663 followers) classic blues, blues, soul blues, blues rock
- Johnny "Guitar" Watson (77,918 followers) blues, funk